Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.

  title={Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.},
  author={P. Sinn and Jessica D. Goreham-Voss and A. C. Arias and M. Hickey and W. Maury and C. P. Chikkanna-Gowda and P. McCray},
  journal={Human gene therapy},
  volume={18 12},
  • P. Sinn, Jessica D. Goreham-Voss, +4 authors P. McCray
  • Published 2007
  • Biology, Medicine
  • Human gene therapy
  • The practical application of gene transfer as a treatment for genetic diseases such as cystic fibrosis or hemophilia has been hindered, in part, by low efficiencies of vector delivery and transgene expression. We demonstrated that a feline immunodeficiency virus (FIV)-based lentiviral vector pseudotyped with the envelope glycoprotein from the baculovirus Autographa californica (GP64) efficiently transduces and persistently expresses a reporter gene in respiratory epithelium in the absence of… CONTINUE READING
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