• DOI:10.1089/HUM.2006.127
Corpus ID: 24939145

Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.

@article{Sinn2007EnhancedGE,
  title={Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.},
  author={P. Sinn and Jessica D. Goreham-Voss and A. C. Arias and M. Hickey and W. Maury and C. P. Chikkanna-Gowda and P. McCray},
  journal={Human gene therapy},
  year={2007},
  volume={18 12},
  pages={
          1244-52
        }
}

P. Sinn, Jessica D. Goreham-Voss, +4 authors P. McCray

Published 2007

Biology, Medicine

Human gene therapy

The practical application of gene transfer as a treatment for genetic diseases such as cystic fibrosis or hemophilia has been hindered, in part, by low efficiencies of vector delivery and transgene expression. We demonstrated that a feline immunodeficiency virus (FIV)-based lentiviral vector pseudotyped with the envelope glycoprotein from the baculovirus Autographa californica (GP64) efficiently transduces and persistently expresses a reporter gene in respiratory epithelium in the absence of… CONTINUE READING

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