Enhanced formation of PGI2, a potent hypotensive substance, by aortic rings and homogenates of the spontaneously hypertensive rat.

@article{PaceAsciak1978EnhancedFO,
  title={Enhanced formation of PGI2, a potent hypotensive substance, by aortic rings and homogenates of the spontaneously hypertensive rat.},
  author={Cecil R. Pace-Asciak and M. C. Carrara and Godha Rangaraj and K. C. Nicolaou},
  journal={Prostaglandins},
  year={1978},
  volume={15 6},
  pages={1005-12}
}
Intact rings and homogenates of aorta from spontaneously hypertensive rats (SHR) contain enhanced capacity over normal rats (NR) to convert arachidonic acid into PGI2. The PGI2 synthetic system in SHR is stimulated to a greater extent than NR by norepinephrine. Indomethacin blocks this stimulation. PGE2 and PGF2alpha were detected in much smaller amounts in homogenates (undetected in rings) but their formation was not enhanced by the hypertensive tissue. The identity of PGI2 was based on 1… CONTINUE READING

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