Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival.

@article{Friess1993EnhancedEO,
  title={Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival.},
  author={Helmut Friess and Yasutsugu Yamanaka and Markus W. B{\"u}chler and Matthias Ebert and Hans Guenther Beger and Leslie I. Gold and Murray Korc},
  journal={Gastroenterology},
  year={1993},
  volume={105 6},
  pages={
          1846-56
        }
}
BACKGROUND Transforming growth factor beta s (TGF-beta s) constitute a family of bifunctional polypeptide growth factors that either inhibit or stimulate cell proliferation. Perturbations in TGF-beta expression and function may lead to loss of negative constraints on cell growth. In this study, we examined TGF-beta expression in human pancreatic cancer. METHODS The distribution of TGF-beta isoforms in 60 human pancreatic cancers was examined using immunohistochemical, Northern blot, and in… CONTINUE READING
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