Enhanced expression of transforming growth factor-beta and its type-I and type-II receptors in human glioblastoma.

@article{Yamada1995EnhancedEO,
  title={Enhanced expression of transforming growth factor-beta and its type-I and type-II receptors in human glioblastoma.},
  author={Nobuhiro Yamada and Miki Kato and Hideki Yamashita and Monica Nist{\'e}r and Kohei Miyazono and Carl-Henrik Heldin and Keiko Funa},
  journal={International journal of cancer},
  year={1995},
  volume={62 4},
  pages={
          386-92
        }
}
Immunohistochemical studies of transforming growth factor-beta (TGF-beta) and its receptors have been carried out on 16 glioma tissues and compared with 5 cases of gliosis. Significantly higher expressions of TGF-beta I, as well as type-I and type-II TGF-beta receptors (T beta R-I and T beta R-II, respectively), were observed in advanced-malignant-glioma tissues when compared with non-tumorous gliosis. Immunoreactivities of TGF-beta and T beta R-I were localized in the cytoplasm of spindle… CONTINUE READING

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