Enhanced expression of transforming growth factor-beta 1 during thyroid hyperplasia in rats.

@article{Logan1994EnhancedEO,
  title={Enhanced expression of transforming growth factor-beta 1 during thyroid hyperplasia in rats.},
  author={Ann Logan and Christopher Smith and G P Becks and Ana Maria Gonzalez and I. D. J. Phillips and David J. Hill},
  journal={The Journal of endocrinology},
  year={1994},
  volume={141 1},
  pages={45-57}
}
Transforming growth factor-beta 1 (TGF-beta 1) has been reported to influence the growth rate and iodine uptake and organification in vitro by isolated thyrocytes. We have determined changes in the expression and presence of TGF-beta 1 within the rat thyroid during goitre induction, and subsequent involution following goitrogen withdrawal. Hyperplastic goitres were induced in adult rats by administration of methimazole together with a low iodine diet for up to 12 weeks. Goitrogen-treated rats… CONTINUE READING

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