Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1

@article{Pham2014EnhancedEO,
  title={Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1},
  author={Duyen H. Pham and Jason A. Powell and Briony L. Gliddon and Paul A. B. Moretti and Anna Tsykin and Maaike van Hoek and Rosalie Kenyon and Gregory J. Goodall and Stuart M Pitson},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={5559-5568}
}
Sphingosine kinase 1 (SK1) is a lipid kinase that catalyses the formation of sphingosine-1-phosphate (S1P). Considerable evidence has implicated elevated cellular SK1 in tumour development, progression and disease severity. In particular, SK1 has been shown to enhance cell survival and proliferation and induce neoplastic transformation. Although S1P has… CONTINUE READING