Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples.

@article{Wang2016EnhancedEO,
  title={Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples.},
  author={X. Wang and Xia Li and Y. Zeng and F. He and Xiao-min Yang and F. Guan},
  journal={International journal of molecular medicine},
  year={2016},
  volume={37 1},
  pages={
          197-206
        }
}
  • X. Wang, Xia Li, +3 authors F. Guan
  • Published 2016
  • Biology, Medicine
  • International journal of molecular medicine
  • Polysialic acid (PSA) is highly expressed during embryonic development, but barely expressed during postnatal development, and may be 're-expressed' in cancer tissues. In this study, motility and migration assays were performed to compare the changes in cell behavior between non-malignant and maligant cells. Next, the expression levels of PSA were evaluated in 4 human and mouse normal breast or breast cancer (BC) cell lines using 1,2-diamino-4,5-methylenedioxybenzene-labeling HPLC technology… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines
    • 109
    • PDF
    Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion.
    • 56
    Glycosylation-related gene expression is linked to differentiation status in glioblastomas undifferentiated cells.
    • 16
    Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma
    • 25
    Cellular changes in boric acid-treated DU-145 prostate cancer cells
    • 78
    • PDF
    Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
    • 70
    • PDF
    Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells.
    • 41
    Polysialyltransferase: a new target in metastatic cancer.
    • 64
    In vitro and in vivo growth of clonal sublines of human small cell lung carcinoma is modulated by polysialic acid of the neural cell adhesion molecule.
    • 117