Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples.

  title={Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples.},
  author={X. Wang and Xia Li and Y. Zeng and F. He and Xiao-min Yang and F. Guan},
  journal={International journal of molecular medicine},
  volume={37 1},
  • X. Wang, Xia Li, +3 authors F. Guan
  • Published 2016
  • Biology, Medicine
  • International journal of molecular medicine
  • Polysialic acid (PSA) is highly expressed during embryonic development, but barely expressed during postnatal development, and may be 're-expressed' in cancer tissues. In this study, motility and migration assays were performed to compare the changes in cell behavior between non-malignant and maligant cells. Next, the expression levels of PSA were evaluated in 4 human and mouse normal breast or breast cancer (BC) cell lines using 1,2-diamino-4,5-methylenedioxybenzene-labeling HPLC technology… CONTINUE READING
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