Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy.

@article{Inaba1996EnhancedEO,
  title={Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy.},
  author={Tsuyoshi Inaba and Shun Ishibashi and Takanari Gotoda and Masahiro Kawamura and Noritsugu Morino and Yoshihisa Nojima and Masanobu Kawakami and Yoshio Yazaki and Nobuhiro Yamada},
  journal={Diabetes},
  year={1996},
  volume={45 4},
  pages={507-12}
}
Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-beta receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high-affinity binding of PDGF-BB on human monocyte-derived macrophages and rabbit aortic medial smooth muscle cells. Northern blot analysis confirmed… CONTINUE READING

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