Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: Possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder

@article{Moon2006EnhancedEO,
  title={Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: Possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder},
  author={Changjong Moon and Heechul Kim and Meejung Ahn and Jae-kwang Jin and Taekyun Shin},
  journal={Journal of Neuroimmunology},
  year={2006},
  volume={172},
  pages={66-72}
}
Netrin-1 is a chemotropic factor that plays an important role as a survival factor in the adult nervous system. To investigate whether netrin-1 is involved in autoimmune injury of the peripheral nervous system (PNS), the temporal expression of netrin-1 protein was analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN). Western blot analysis revealed a significant increase in the level of netrin-1 protein in the sciatic nerves of rats on days 11 to 24 post… CONTINUE READING