Enhanced expression of haem oxygenase-1 by nitric oxide and antiinflammatory drugs in NIH 3T3 fibroblasts.

@article{Alcaraz2000EnhancedEO,
  title={Enhanced expression of haem oxygenase-1 by nitric oxide and antiinflammatory drugs in NIH 3T3 fibroblasts.},
  author={Mar{\'i}a Jos{\'i} Alcaraz and A{\"i}da Habib and Marilyne Lebret and Christophe A Cr{\'e}minon and Sylviane L{\'e}vy-Toledano and Jacques Maclouf},
  journal={British journal of pharmacology},
  year={2000},
  volume={130 1},
  pages={57-64}
}
1. Haem oxygenase-1 (HO-1) can exert protective effects against oxidative stress and inflammation. Fibroblasts participate in inflammatory responses where they produce high levels of prostaglandins (PGs) and nitric oxide (NO). However, little is known of the presence of HO-1 in these cells and the possible interactions among these pathways. Incubation of cells with NO donors, spermine nonoate (SPNO) and S-nitroso-N-acetylpenicillamine (SNAP), induced a dose- and time-dependent expression of HO… CONTINUE READING

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