Enhanced expression of aquaporin 4 in human brain with inflammatory diseases


Aquaporin 4 (AQP4), one of the water channel proteins on the plasma membrane of astrocytes, is up-regulated in various conditions with brain edema. Possible participation of AQP4 in various inflammatory lesions, more or less associated with edema, was examined in human autopsied brains. Immunohistochemistry was used to investigate AQP4 expression in… (More)
DOI: 10.1007/s00401-005-1052-2


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