Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction.

@article{Shyu2004EnhancedEO,
  title={Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction.},
  author={Kou-Gi Shyu and Yao-jen Liang and Hang K Chang and B Wang and J Z Leu and Peiliang Kuan},
  journal={Journal of biomedical science},
  year={2004},
  volume={11 2},
  pages={163-71}
}
Modulation of Tie2 receptor activity by angiopoietin ligands is crucial for angiogenesis, blood vessel maturation, and vascular endothelium integrity. The role of the angiopoietin (Ang) and Tie system in myocardial infarction is not well understood. To investigate the participation of the Ang/Tie in myocardial infarction, adult Sprague-Dawley rats with ligation of the left anterior descending coronary artery to induce myocardial infarction were studied. Ang1, Ang2, Tie1, and Tie2 were measured… CONTINUE READING

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