Enhanced expression of Pafah1b1 causes over-migration of cerebral cortical neurons into the marginal zone

Abstract

Mutations of PAFAH1B1 cause classical lissencephaly in humans. In addition, duplications and triplications of PAFAH1B1 are found in individuals with intellectual disability and other neurological disorders suggesting that proper brain development is highly sensitive to the PAFAH1B1 dosage. To examine the effect of PAFAH1B1 over-dosage in neural development… (More)
DOI: 10.1007/s00429-017-1497-9

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