Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.

@article{Zhang2010EnhancedEO,
  title={Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.},
  author={Y J Zhang and Ronnie L Yeager and Yuji Tanaka and Curtis D. Klaassen},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={245 3},
  pages={326-34}
}
Oxidative stress has been proposed as an important promoter of the progression of fatty liver diseases. The current study investigates the potential functions of the Nrf2-Keap1 signaling pathway, an important hepatic oxidative stress sensor, in a rodent fatty liver model. Mice with no (Nrf2-null), normal (wild type, WT), and enhanced (Keap1 knockdown, K1-kd) expression of Nrf2 were fed a methionine- and choline-deficient (MCD) diet or a control diet for 5 days. Compared to WT mice, the MCD diet… CONTINUE READING
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