Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?

@article{Rath2006EnhancedEO,
  title={Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?},
  author={Timo Rath and Martin Roderfeld and Juergen Graf and Sandra Wagner and Ann-Kathrin Vehr and C F Dietrich and Andreas Geier and Elke Roeb},
  journal={Inflammatory bowel diseases},
  year={2006},
  volume={12 11},
  pages={
          1025-35
        }
}
Matrix metalloproteinases (MMPs) are responsible for the turnover and degradation of extracellular matrix. They play a crucial role in the growth and migration of colorectal carcinoma cells. Colorectal carcinomas are characterized by enhanced expression of MMP-2, MMP-9, MMP-7, and MMP-13. The aim of this study was to determine the expression levels of MMP-2, MMP-9, MMP-7, MMP-13, and MMP-14 and their specific inhibitor TIMP-1 in inflammatory bowel diseases and precancerous lesions of the colon… CONTINUE READING

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