Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.

@article{Martin2003EnhancedER,
  title={Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.},
  author={Lesley-Ann Martin and Ian Farmer and Stephen R. D. Johnston and Simak Ali and Chris Marshall and Mitch Dowsett},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={30458-68}
}
The mechanisms involved in resistance to estrogen deprivation are of major importance for optimal patient therapy and the development of new drugs. Long term culture of MCF-7 cells in estrogen (E2)-depleted medium (long term estrogen deprivation; LTED) results in hypersensitivity to E2 coinciding with elevated levels of estrogen receptor (ER) alpha phosphorylated on Ser118 and MAPK, together with several of its downstream targets associated previously with ERalpha phosphorylation. Our data… CONTINUE READING
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