Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

@article{Battegay1994EnhancedEO,
  title={Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.},
  author={Manuel Battegay and Demetrius Moskophidis and Amin Rahemtulla and Hans Hengartner and Tak W Mak and Rolf Martin Zinkernagel},
  journal={Journal of virology},
  year={1994},
  volume={68 7},
  pages={4700-4}
}
CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4-/- mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 10(2) PFU) because of an effective CD8+ cytotoxic T-cell (CTL) response. In contrast, infection with a high dose (2 x 10(6) PFU) of LCMV strain… CONTINUE READING
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