Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency.

@article{Lang2002EnhancedEA,
  title={Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency.},
  author={Karl S Lang and Benjamin Roll and Svetlana Myssina and Markus Schittenhelm and Hans-Gerhard Scheel-Walter and Lothar Kanz and Jasmin Fritz and Florian Lang and Stephan M Huber and Thomas Wieder},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2002},
  volume={12 5-6},
  pages={365-72}
}
Erythrocyte diseases such as sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency decrease the erythrocyte life span, an effect contributing to anemia. Most recently, erythro-cytes have been shown to undergo apoptosis upon increase of cytosolic Ca(2+) activity. The present study has been performed to explore whether sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency enhance the sensitivity of erythrocytes to osmotic shock, oxidative… CONTINUE READING
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