Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7

Abstract

Annexin A7 is a ubiquitously expressed Ca2+- and phospholipid-binding protein. Erythrocytes from mice lacking annexin A7 (anxA7 −/− ) are deformed and relatively resistant to osmotic swelling. In normal erythrocytes, hyperosmotic shock, Cl− removal, and energy depletion (glucose removal) trigger PGE2 formation, which stimulates Ca2+-permeable cation… (More)
DOI: 10.1007/s00424-010-0829-x

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