Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing.

@article{Terao2011EnhancedET,
  title={Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing.},
  author={Mika Terao and Akiko Ishikawa and Susumu Nakahara and Akihiro Kimura and Arisa Kato and Kenta Moriwaki and Yoshihiro Kamada and Hiroyuki Murota and Naoyuki Taniguchi and Ichiro Katayama and Eiji Miyoshi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 32},
  pages={28303-11}
}
N-Acetylglucosaminyltransferase V (GnT-V) catalyzes the β1,6 branching of N-acetylglucosamine on N-glycans. GnT-V expression is elevated during malignant transformation in various types of cancer. However, the mechanism by which GnT-V promotes cancer progression is unclear. To characterize the biological significance of GnT-V, we established GnT-V transgenic (Tg) mice, in which GnT-V is regulated by a β-actin promoter. No spontaneous cancer was detected in any organs of the GnT-V Tg mice… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Emt: 2016

View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…