Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals.

@article{Rutitzky2005EnhancedEI,
  title={Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals.},
  author={Laura I. Rutitzky and H{\'e}ctor J. Hern{\'a}ndez and Young-Sun Yim and David E Ricklan and Eduardo Finger and C. Mohan and Inga Peter and Edward K. Wakeland and Miguel J. Stadecker},
  journal={Journal of immunology},
  year={2005},
  volume={174 1},
  pages={435-40}
}
The genetic basis of dissimilar immunopathology development among mouse strains infected with Schistosoma mansoni is not known. We performed a multipoint parametric linkage analysis on a cohort of F(2) mice, offspring of brother-sister mating between (high pathology CBA x low pathology BL/6)F(1) mice, to examine whether the observed differences in the type of immune response or the extent of hepatic immunopathology are linked to any particular genomic intervals. The F(2) mice exhibited cytokine… CONTINUE READING

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