Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters

@article{Zhang2007EnhancedEO,
  title={Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters},
  author={Feng Zhang and Yuhong Li and Ming-Wen Fan and Rong Jia and Qing-an Xu and Ji-hua Guo and Fei Yu and Qi-wei Tian},
  journal={Acta Pharmacologica Sinica},
  year={2007},
  volume={28},
  pages={1236-1242}
}
AbstractAim:To evaluate the comparative immunogenicity and protective efficacy of the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) fusion anti-caries DNA vaccines pGJA-P/VAX1, pGJA-P, and non-fusion anti-caries DNA construct pGLUA-P in hamsters. In addition, the ability of CTLA-4 to target pGJA-P/VAX1-encoding antigen to dendritic cells was tested in vitro.Methods:All DNA constructs contain genes encoding the A-P regions of a cell surface protein (PAc) and the glucan binding (GLU… CONTINUE READING