Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.

@article{Riese2013EnhancedER,
  title={Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.},
  author={Matthew J. Riese and L. Sh. Wang and Edmund K. Moon and Rohan P. Joshi and Anjana Ranganathan and Carl H June and Gary A Koretzky and Steven M. Albelda},
  journal={Cancer research},
  year={2013},
  volume={73 12},
  pages={3566-77}
}
Recent clinical trials have shown promise in the use of chimeric antigen receptor (CAR)-transduced T cells; however, augmentation of their activity may broaden their clinical use and improve their efficacy. We hypothesized that because CAR action requires proteins essential for T-cell receptor (TCR) signal transduction, deletion of negative regulators of these signaling pathways would enhance CAR signaling and effector T-cell function. We tested CAR activity and function in T cells that lacked… CONTINUE READING
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