Published 1997 in British journal of clinical pharmacology
Triazolam, a triazolobenzodiazepine hypnotic agent, is metabolized by CYP3A4. Diltiazem is an inhibitor of this isozyme. The aim of this study was to determine if diltiazem affects plasma concentrations of triazolam in humans.
We investigated the interaction between triazolam and diltiazem in a randomized, three-phase crossover study. Seven… CONTINUE READING