Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport

@article{Xiong2006EnhancedEO,
  title={Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport},
  author={Fu Xiong and Shaobo Xiao and Meijuan Yu and Wanyi Li and Hui Zheng and Yan-chang Shang and Funing Peng and Cui-ping Zhao and Wenliang Zhou and Huan Chen and Liurong Fang and Jeffrey S. Chamberlain and Cheng Zhang},
  journal={BMC Neuroscience},
  year={2006},
  volume={8},
  pages={50 - 50}
}
Duchenne musclar dystrophy (DMD) is an X-linked recessive disease caused by mutations of dystrophin gene, there is no effective treatment for this disorder at present. Plasmid-mediated gene therapy is a promising therapeutical approach for the treatment of DMD. One of the major issues with plasmid-mediated gene therapy for DMD is poor transfection efficiency and distribution. The herpes simplex virus protein VP22 has the capacity to spread from a primary transduced cell to surrounding cells and… CONTINUE READING

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