Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A

@inproceedings{Qi2011EnhancedEA,
  title={Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A},
  author={Jianping Qi and Jie Zhen Zhuang and Weiqiang Wu and Yi Lu and Yunmei Song and Zhetao Zhang and Jia Jia and Qineng Neng Ping},
  booktitle={International journal of nanomedicine},
  year={2011}
}
BACKGROUND A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs. METHODS The microemulsion formulation was optimized using a pseudoternary phase diagram, comprising propylene glycol dicaprylocaprate (PG), Cremophor(®) RH40, and water (30/46/24 w/w). RESULTS The… CONTINUE READING

Similar Papers

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Improving oral bioavailability of metformin hydrochloride using water-in-oil microemulsions and analysis of phase behavior after dilution.

  • International journal of pharmaceutics
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2008
VIEW 2 EXCERPTS

Morphological observations on a lipid-based drug delivery system during in vitro digestion.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2007
VIEW 1 EXCERPT

Oral lipid-based formulations.

  • Advanced drug delivery reviews
  • 2007