Enhanced ectodysplasin‐A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form
@article{Mou2008EnhancedER, title={Enhanced ectodysplasin‐A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form}, author={C. Mou and Helen A. Thomason and Pamela M. Willan and Christopher D. Clowes and W. E. Harris and Caroline F Drew and J. Dixon and M. Dixon and D. Headon}, journal={Human Mutation}, year={2008}, volume={29} }
Hair morphology differs dramatically between human populations: people of East Asian ancestry typically have a coarse hair texture, with individual fibers being straight, of large diameter, and cylindrical when compared to hair of European or African origin. Ectodysplasin‐A receptor (EDAR) is a cell surface receptor of the tumor necrosis factor receptor (TNFR) family involved in the development of hair follicles, teeth, and sweat glands. Analyses of genome‐wide polymorphism data from multiple… CONTINUE READING
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References
SHOWING 1-10 OF 45 REFERENCES
A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.
- Biology, Medicine
- Human molecular genetics
- 2008
- 190
- PDF
Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2006
- 57
- PDF
Stimulation of ectodermal organ development by Ectodysplasin-A1.
- Biology, Medicine
- Developmental biology
- 2003
- 250
Edar signaling in the control of hair follicle development.
- Biology, Medicine
- The journal of investigative dermatology. Symposium proceedings
- 2005
- 66
Involvement of the Edar signaling in the control of hair follicle involution (catagen).
- Biology, Medicine
- The American journal of pathology
- 2006
- 42
Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression
- Biology, Medicine
- Development
- 2007
- 167
- PDF
Involvement of a novel Tnf receptor homologue in hair follicle induction
- Biology, Medicine
- Nature Genetics
- 1999
- 357
Permanent correction of an inherited ectodermal dysplasia with recombinant EDA
- Biology, Medicine
- Nature Medicine
- 2003
- 177
- PDF