Enhanced early immune response of leptospiral outer membrane protein LipL32 stimulated by narrow band mid-infrared exposure.

  title={Enhanced early immune response of leptospiral outer membrane protein LipL32 stimulated by narrow band mid-infrared exposure.},
  author={Chung-Hung Hong and Ming-Ru Tang and Shen-Hsing Hsu and Ching-Hsu Yang and Chi-Shin Tseng and Yi-Ching Ko and Che-Shao Guo and Chih-Wei Yang and Si-Chen Lee},
  journal={Journal of photochemistry and photobiology. B, Biology},
Peptidoglycan mediates Leptospira outer membrane protein Loa22 to toll-like receptor 2 for inflammatory interaction: a novel innate immune recognition
LPGN mediates interactions between Loa22 and TLR2 and induces downstream signals to trigger inflammatory responses and reveals a novel binding mechanism for the innate immune system.
Toll-like receptor 4/nuclear factor-kappa B pathway is involved in activating microphages by polysaccharides isolated from Fagopyrum esculentum
It is demonstrated that BPFs can activate microphages and Toll-like receptor 4 (TLR4)/NF-κB pathway is involved in the induction of NO and TNF-α in macrophages by BPFs.
Optical Fiber Refractive Index Sensor Based on the SPR Using a Multiple D-shaped Ag Nanowire
This study proposes the simulation of multiple D-shaped Ag nanowires (AgNWs) based on a highly sensitive surface plasmon resonance (SPR) optical fiber external refractive index (RI) sensor. The
The role of temperature in plasmon sensors in physical and biological research
Recently, sensors that use the phenomenon of plasmon resonance have been widely used [1]. In this case, biosensors are of particular interest [2].
High-beam-quality 2.1  µm pumped mid-infrared type-II phase-matching BaGa4Se7 optical parametric oscillator with a ZnGeP2 amplifier.
A tunable 2.1 µm pumped mid-infrared type-II phase-matching BaGa4Se7 (BGSe) optical parametric oscillator (OPO) with ZnGeP2 (ZGP) OPA system, which is over a 50% promotion on the previous M2 results of single BGSe OPO.


Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells.
Tubulointerstitial nephritis is a cardinal renal manifestation in leptospirosis and LipL32, the major lipoprotein component of leptospiral outer membrane proteins (OMPs), induces a robust
Active Components of Leptospira Outer Membrane Protein LipL32 to Toll-Like Receptor 2
A detailed mechanism of the interaction between LipL32 and TLR2 and the residues involved in complex formation is provided and β1β2, loop-α3-loop, and α4 domains of Lip L32 play vital roles in LipL 32-TLR2 complex formation.
Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae
The results support the use of zebrafish as a model organism for studying the disease mechanism of leptospiral infection and give some clues to the potential virulence of LipL32.
Leptospira and Inflammation
It is proposed that in addition to Toll-like receptors, Na/K-ATPase may play a role in the innate response to leptospirosis infection, and may contribute to inflammatory and metabolic alteration in this syndrome.
Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity
This double action by inducing AMPs and enhancing epithelial integrity for one APD compound is unique and taken as a positive indication for host directed therapy (HDT) and is in line with improved stewardship in healthcare.
The Leptospira outer membrane protein LipL32 induces tubulointerstitial nephritis-mediated gene expression in mouse proximal tubule cells.
It is demonstrated that LipL32 is a major component of pathogenic leptospira outer membrane proteins involved in the pathogenesis of tubulointerstitial nephritis.
Leptospiral membrane proteins stimulate pro-inflammatory chemokines secretion by renal tubule epithelial cells through toll-like receptor 2 and p38 mitogen activated protein kinase.
  • C. Hung, Chiz-Tzung Chang, Chih-Wei Yang
  • Biology, Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2006
These findings demonstrate that activation of p38 MAPK and release of chemokines by LMPS are mediated by TLR2 in renal proximal tubule cells and implicate the crucial role of innate immunity in leptospira-induced tubulointerstitial nephritis.
Leptospirosis: Aspects of Innate Immunity, Immunopathogenesis and Immune Evasion From the Complement System
The knowledge of evasion strategies employed by pathogenic leptospires to subvert the immune system is of extreme importance as they may represent targets for the development of new treatments and prophylactic approaches inLeptospirosis.
Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury.
Endothelial injury biomarkers are associated with leptospirosis-associated renal damage and this association remained even after multivariate analysis including other AKI-associated characteristics.