Enhanced dopamine uptake in the striatum following repeated restraint stress.

@article{Copeland2005EnhancedDU,
  title={Enhanced dopamine uptake in the striatum following repeated restraint stress.},
  author={Benjamin J. Copeland and Norton H. Neff and Maria Hadjiconstantinou},
  journal={Synapse},
  year={2005},
  volume={57 3},
  pages={
          167-74
        }
}
In mice administered chronic stress--repeated overnight restraint stress for 7 days--there was a prolonged enhancement of dopamine (DA) uptake into synaptosomes. The mRNA for the DA transporter (DAT) was found to be concomitantly increased in the midbrain, as was the binding of the transporter ligand mazindol to DAT in the nucleus accumbens and caudate-putamen. Kinetic analysis showed an increase in Vmax for DA, with little change in Km. No changes in tyrosine hydroxylase activity and tissue DA… CONTINUE READING
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