Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice.

@article{Zhao2009EnhancedDN,
  title={Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice.},
  author={Di Zhao and Dale M. Seth and L Gabriel Navar},
  journal={Hypertension},
  year={2009},
  volume={54 1},
  pages={120-6}
}
Chronic angiotensin II (Ang II) infusions enhance urinary excretion of angiotensinogen, suggesting augmentation of distal nephron sodium reabsorption. To assess whether chronic Ang II infusions (15 ng/min for 2 weeks) enhance distal nephron sodium reabsorption, we compared sodium excretion before and after blockade of the 2 main distal nephron sodium transporters by IV amiloride (5 mg/kg of body weight) plus bendroflumethiazide (12 mg/kg of body weight) in male C57/BL6 anesthetized control mice… CONTINUE READING