Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

@inproceedings{Valley2015EnhancedDD,
  title={Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer},
  author={Christopher C. Valley and Donna J. Arndt-Jovin and Narain Karedla and Mara P. Steinkamp and Alexey I Chizhik and William S. Hlavacek and Bridget S. Wilson and Keith A. Lidke and Diane S. Lidke and C M Heldin},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate ligand-independent signaling are common in non-small cell lung cancer (NSCLC), including kinase domain mutations L858R (also called L834R) and exon 19 deletions (e.g., ΔL747-P753insS), which collectively make up nearly 90% of mutations in NSCLC. The molecular mechanisms by which these mutations confer constitutive activity… CONTINUE READING
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