Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.

@article{Mosca2013EnhancedDR,
  title={Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.},
  author={Barbara Mosca and Osvaldo Delbono and Maria Laura Messi and Leda Bergamelli and Zhong-Min Wang and Mirko Vukcevic and Rub{\'e}n L{\'o}pez and Susan Treves and Miyuki Nishi and Hiroshi Takeshima and Cecilia Paolini and Marta Martini and Giorgio Rispoli and Feliciano Protasi and Francesco Zorzato},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={1541}
}
Muscle strength declines with age in part due to a decline of Ca(2+) release from sarcoplasmic reticulum calcium stores. Skeletal muscle dihydropyridine receptors (Ca(v)1.1) initiate muscle contraction by activating ryanodine receptors in the sarcoplasmic reticulum. Ca(v)1.1 channel activity is enhanced by a retrograde stimulatory signal delivered by the ryanodine receptor. JP45 is a membrane protein interacting with Ca(v)1.1 and the sarcoplasmic reticulum Ca(2+) storage protein calsequestrin… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 52 references

Dynapenia and aging: an update.

The journals of gerontology. Series A, Biological sciences and medical sciences • 2012

an update

T. M. Manini, Clark, B. C. Dynapenia, aging
J. Gerontol. A Biol. Sci. Med. Sci. 67, 28–40 • 2012
View 1 Excerpt

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