Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice.

@article{Bracke2010EnhancedDO,
  title={Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice.},
  author={Ken R Bracke and Mieke A. Dentener and Eleni D Papakonstantinou and Juanita H. J. Vernooy and Tine Demoor and Nele S. A. Pauwels and Jack P. M. Cleutjens and Robert Jan van Suylen and Guy F Joos and Guy G Brusselle and Emiel F. M. Wouters},
  journal={American journal of respiratory cell and molecular biology},
  year={2010},
  volume={42 6},
  pages={753-61}
}
Chronic obstructive pulmonary disease (COPD) is characterized by infiltration of inflammatory cells, destruction of lung parenchyma, and airway wall remodeling. Hyaluronan (HA) is a component of the extracellular matrix, and low-molecular-weight (LMW) HA fragments have proinflammatory capacities. We evaluated the presence of HA in alveolar and airway walls of C57BL/6 mice that were exposed to air or cigarette smoke (CS) for 4 weeks (subacute) or 24 weeks (chronic). We measured deposition of the… CONTINUE READING
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