Enhanced delivery of boronophenylalanine for neutron capture therapy by means of intracarotid injection and blood-brain barrier disruption.

@article{Yang1996EnhancedDO,
  title={Enhanced delivery of boronophenylalanine for neutron capture therapy by means of intracarotid injection and blood-brain barrier disruption.},
  author={Weilian Yang and Rolf Barth and D. E. O. S. Carpenter and Melvin L. Moeschberger and Joseph H. Goodman},
  journal={Neurosurgery},
  year={1996},
  volume={38 5},
  pages={985-92}
}
There has been increasing interest in the possible use of boronophenylalanine as a capture agent for boron neutron capture therapy of brain tumors. The purpose of the present study was to determine whether the uptake of boronophenylalanine in F98 glioma-bearing rats could be enhanced by means of intracarotid (i.c.) injection with or without blood-brain barrier disruption (BBB-D). Glioma cells (10(5)) were stereotactically implanted into the right cerebral hemisphere of Fischer rats, and 12 days… CONTINUE READING
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