Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.

  title={Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.},
  author={Eugenia K. Page and Andrew Joseph Page and Jean Kwun and Adriana C Gibby and F. Leopardi and Joe B Jenkins and Elizabeth A. Strobert and Mingqing Song and Randolph Hennigar and Neal N. Iwakoshi and Stuart J Knechtle},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={12 9},
Chronic allograft rejection is a major impediment to long-term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidence associating alloantibodies with the development of chronic rejection. Nearly a third of transplant recipients develop de novo antibodies, for which no established therapies are effective at preventing or eliminating, highlighting the need for a nonhuman primate model of antibody-mediated rejection… CONTINUE READING
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