Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.

@article{Im2009EnhancedCO,
  title={Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.},
  author={Young-Sam Im and Hea Kyeong Shin and Hye-Ryun Kim and So-Hee Jeong and Seung-Ryul Kim and Yong-Min Kim and Do Hyung Lee and Seong-Ho Jeon and Hyeon-Woo Lee and J Choi},
  journal={Molecules and cells},
  year={2009},
  volume={28 2},
  pages={119-24}
}
Anti cancer agent 5-FU (Fluoro Uracil) is a prodrug that can be metabolized and then activated to interfere with RNA and DNA homeostasis. However, the majority of administered 5-FU is known to be catabolized in vivo in the liver where Dihydropyrimidine dehydrogenase (DPD) is abundantly expressed to degrade 5-FU. The biological factors that correlate with… CONTINUE READING