Enhanced contact hypersensitivity by delayed T-helper 2 response in BALB/c mice.

@article{Hayashi2009EnhancedCH,
  title={Enhanced contact hypersensitivity by delayed T-helper 2 response in BALB/c mice.},
  author={Toshiharu Hayashi and Sachiko Hara and Keiko Hasegawa},
  journal={Allergy and asthma proceedings},
  year={2009},
  volume={30 4},
  pages={
          449-57
        }
}
T-helper (Th) 1/Th2 balance determines the direction of contact hypersensitivity (CHS). To clarify the immunopathogenesis of contact dermatitis, 2,4-dinitrofluorobenzene (DNFB)-induced CHS reaction was compared between the BALB/c and C57BL/6 mice. The two strains were sensitized with DNFB systemically and challenged with DNFB locally. The CHS reaction in BALB/c mice was intense compared with that in C57BL/6 mice at 24 and 48 hours post-DNFB challenge. The dermal lesions were characterized by… CONTINUE READING