Enhanced colorectal cancer metastases in the alcohol-injured liver

@article{Mohr2017EnhancedCC,
  title={Enhanced colorectal cancer metastases in the alcohol-injured liver},
  author={Ashley M. Mohr and John J. Gould and Jacy L. Kubik and Geoffrey A Talmon and Carol A Casey and Peter Vaughn Thomas and Dean J. Tuma and B Mcvicker},
  journal={Clinical & Experimental Metastasis},
  year={2017},
  volume={34},
  pages={171-184}
}
Metastatic liver disease is a major cause of mortality in colorectal cancer (CRC) patients. Alcohol consumption is a noted risk factor for secondary cancers yet the role of alcoholic liver disease (ALD) in colorectal liver metastases (CRLM) is not defined. This work evaluated tumor cell colonization in the alcoholic host liver using a novel preclinical model of human CRC liver metastases. Immunocompromised Rag1-deficient mice were fed either ethanol (E) or isocaloric control (C) diets for 4… CONTINUE READING
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