Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner.

@article{Wang2009EnhancedCO,
  title={Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner.},
  author={Zhiqiang Wang and Huanhuan Wang and Jiaying Wu and Danyan Zhu and X. Zhang and Lili Ou and Yongping Yu and Y. Lou},
  journal={Chemico-biological interactions},
  year={2009},
  volume={179 2-3},
  pages={
          375-85
        }
}
A previous small molecule screen demonstrated that some prenylflavonoids can promote neuronal differentiation from mouse embryonic stem (ES) cells based on morphologic criteria. Here we build on this observation and examine the neuronal subtypes induced by icaritin, a compound screened, and the molecular events underlying the differentiation. In the presence of icaritin, the number of neural rosettes in embryoid bodies (EBs) expressing nestin efficiently increased and the neuroectodermal gene… Expand
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