Corpus ID: 16508664

Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines.

@article{Selvakumaran2003EnhancedCC,
  title={Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines.},
  author={M. Selvakumaran and Debra A Pisarcik and R. Bao and A. Yeung and T. Hamilton},
  journal={Cancer research},
  year={2003},
  volume={63 6},
  pages={
          1311-6
        }
}
Ovarian cancer is the leading cause of death among women from gynecological malignancies inthe United States. Resistance to the chemotherapeutic agent cisplatin isa major limitation for the successful treatment of ovarian cancer. In an effort to overcome the cisplatin resistance problem in ovarian cancer treatment, we have sought to enhance cisplatin cytotoxicity by perturbing the nucleotide excision repair (NER) pathway. The NER pathway is responsible for repairing cisplatin bound to DNA… Expand
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