Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment.

@article{Gerven2017EnhancedCS,
  title={Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment.},
  author={Laura Van Gerven and Yeranddy A Alpizar and Brecht Steelant and Ina Callebaut and I Kortekaas Krohn and Mira M Wouters and Francois Vermeulen and Guy E. E. Boeckxstaens and Karel Talavera and Peter W Hellings},
  journal={The Journal of allergy and clinical immunology},
  year={2017},
  volume={140 2},
  pages={437-446.e2}
}
BACKGROUND The therapeutic action of capsaicin treatment in patients with idiopathic rhinitis (IR) is based on ablation of the transient receptor potential cation channel subfamily V, receptor 1 (TRPV1)-substance P nociceptive signaling pathway. However, the functional consequences of capsaicin treatment on nasal nerve activation and the association between the reduction in nasal hyperreactivity (NHR) and response to capsaicin treatment remain unknown. OBJECTIVE We sought to study the effects… CONTINUE READING
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