Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates.

@article{Hegeds2012EnhancedCU,
  title={Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates.},
  author={R{\'o}zsa Heged{\"u}s and Marilena Manea and Erika Orb{\'a}n and Ildik{\'o} Szab{\'o} and {\'E}va {\'I}risz Kiss and {\'E}va Sipos and G{\'a}bor Halmos and G{\'a}bor Mező},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={56},
  pages={155-65}
}
Here we report on the synthesis and biochemical characterization (enzymatic stability, cellular uptake, in vitro antitumor activity, membrane interaction and GnRH-receptor binding affinity) of novel short-chain fatty acid (SCFA) acylated daunorubicin-GnRH-III bioconjugates, which may serve as drug delivery systems for targeted cancer chemotherapy. Ser in… CONTINUE READING