Enhanced cellular uptake and gene silencing activity of siRNA molecules mediated by chitosan-derivative nanocomplexes.

@article{GuzmanVillanueva2014EnhancedCU,
  title={Enhanced cellular uptake and gene silencing activity of siRNA molecules mediated by chitosan-derivative nanocomplexes.},
  author={Diana Guzman-Villanueva and Ibrahim M. El-Sherbiny and Alexander V Vlassov and Dea Herrera-Ruiz and Hugh D C Smyth},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={473 1-2},
  pages={579-90}
}
The RNA interference (RNAi) constitutes a conservative mechanism in eukaryotic cells that induces silencing of target genes. In mammalians, the RNAi is triggered by siRNA (small interfering RNA) molecules. Due to its potential in silencing specific genes, the siRNA has been considered a potential alternative for the treatment of genetic and acquired diseases. However, the siRNA therapy has been limited by its low stability and rapid degradation in presence of nucleases, low cellular uptake, and… CONTINUE READING