Enhanced cellular responses and environmental sampling within inner foreskin explants: implications for the foreskin's role in HIV transmission

Abstract

The decrease in HIV acquisition after circumcision suggests a role for the foreskin in HIV transmission. However, the mechanism leading to protection remains undefined. Using tissue explant cultures we found that Langerhans cells (LCs) in foreskin alter their cellular protein expression in response to external stimuli. Furthermore, we observe that upon… (More)
DOI: 10.1038/mi.2010.18

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