Enhanced cell uptake of superparamagnetic iron oxide nanoparticles functionalized with dendritic guanidines.

@article{Martin2008EnhancedCU,
  title={Enhanced cell uptake of superparamagnetic iron oxide nanoparticles functionalized with dendritic guanidines.},
  author={Amanda L. Martin and Lisa M Bernas and Brian K. Rutt and Paula J. Gareau Foster and Elizabeth R Gillies},
  journal={Bioconjugate chemistry},
  year={2008},
  volume={19 12},
  pages={2375-84}
}
Magnetic resonance imaging (MRI) is a powerful tool for the diagnosis of disease and the study of biological processes such as cancer metastasis and inflammation. Superparamagnetic iron oxide (SPIO) nanoparticles have been shown to be effective contrast agents for labeling cells to provide high sensitivity in MRI, but this sensitivity depends on the ability to label cells with sufficient quantities of SPIO, which can be challenging for nonphagocytic cells such as cancer cells. To address this… CONTINUE READING
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