Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin.

@article{Lian2006EnhancedCS,
  title={Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin.},
  author={Zhaorui Lian and Jie Liu and Li Li and Xianxing Li and Marcy M Clayton and Meng-chao Wu and Hong-yang Wang and Patrick Arbuthnot and Michael Kew and Dai-ming Fan and Mark Alan Feitelson},
  journal={Hepatology},
  year={2006},
  volume={43 3},
  pages={415-24}
}
Intrahepatic expression of hepatitis B x antigen (HBxAg) is associated with the development of hepatocellular carcinoma (HCC), perhaps through trans-activation of selected cellular genes. When this was examined by PowerBlot analysis, upregulated levels of beta-catenin and several known beta-catenin effectors were observed in HBxAg-positive compared with HBxAg-negative HepG2 cells. When HBxAg was introduced into Hep3B cells, upregulated expression of wild-type beta-catenin was observed. This was… CONTINUE READING

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