Enhanced cell immune responses to hepatitis c virus core by novel heterologous DNA prime/lambda nanoparticles boost in mice

@article{Saeedi2014EnhancedCI,
  title={Enhanced cell immune responses to hepatitis c virus core by novel heterologous DNA prime/lambda nanoparticles boost in mice},
  author={Atefeh Saeedi and Amir Ghaemi and Alijan Tabarraei and Abdolvahab Moradi and Ali Gorji and Shahriar Semnani Semnani and Hoorieh Soleimanjahi and Ahmad Hosseinzadeh Adli and Seyed Yones Hosseini and Mohammad Ali Vakili},
  journal={Virus Genes},
  year={2014},
  volume={49},
  pages={11-21}
}
Hepatitis C virus (HCV) is a worldwide problem which does not have an effective vaccine and more than 170 million people worldwide are chronically infected by HCV. T cell responses are associated with spontaneous clearance of HCV infection. We report here the development of recombinant Lambda bacteriophage nanoparticles encoding HCV Core antigen. The aim of this study was to investigate the antigen-specific immune responses triggered in mice by different prime–boost combinations of DNA and… CONTINUE READING