Enhanced caveolae-mediated endocytosis by diagnostic ultrasound in vitro.

@article{Lionetti2009EnhancedCE,
  title={Enhanced caveolae-mediated endocytosis by diagnostic ultrasound in vitro.},
  author={Vincenzo Lionetti and Antonio Fittipaldi and Silvia Agostini and Mauro Giacca and Fabio A. Recchia and Eugenio Picano},
  journal={Ultrasound in medicine & biology},
  year={2009},
  volume={35 1},
  pages={136-43}
}
The modulation of cellular endothelial permeability is a desirable goal for targeted delivery of labels and therapeutic macromolecules; the underlying mechanisms, however, remains poorly understood. Here, we hypothesize that a higher endothelial permeability may result as an outcome of selective enhancement of caveolar endocytosis by ultrasound (US), in the frequency and intensity range of current clinical diagnostic use. To assess the role of free radicals in this phenomenon, we exposed… CONTINUE READING

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