Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease

BACKGROUND Studies in animals suggest that the noradrenergic system arising from the locus coeruleus (LC) and dopaminergic pathways mutually influence each other. Little is known however, about the functional state of the LC in patients with Parkinson disease (PD). METHODS We retrospectively reviewed clinical and imaging data of 94 subjects with PD at an… CONTINUE READING