Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.

@article{Bayne2005EnhancedCO,
  title={Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.},
  author={Anne-C{\'e}cile V. Bayne and Robin J. Mockett and William C. Orr and Rajindar S. Sohal},
  journal={The Biochemical journal},
  year={2005},
  volume={391 Pt 2},
  pages={277-84}
}
The generation of superoxide anion radicals (O2*-) and hydrogen peroxide (H2O2) during mitochondrial respiration has been widely postulated to be causally linked to the aging process. The hypothesis that a specific enhancement of mitochondrial O2*-/H2O2 catabolism would delay age-associated physiological changes and extend the lifespan was tested by simultaneous overexpression of MnSOD (manganese superoxide dismutase) and catalase, ectopically targeted to the mitochondrial matrix of transgenic… CONTINUE READING